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Longevity Study → Investigation 16

Does Poor Sleep Predict Health Decline?

24,155 Health and Retirement Study (HRS) respondents aged 50+ with sleep-quality data. Does adding these self-reported measures improve prediction beyond health, depression, and function?

The Question

Sleep is one of the most-discussed health behaviors — poor sleep is linked to cardiovascular disease, diabetes, depression, and mortality. But sleep quality is also deeply entangled with the conditions it predicts. If you already know someone has chronic pain, depression, and three chronic diseases, does knowing they sleep poorly add any new information? This investigation tests whether sleep measures improve health decline prediction beyond what standard clinical features already capture.

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People Tracked
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Health Declined
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No-Sleep AUC
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+Sleep AUC

ADM Prediction (Made Before Running Models)

Predicted winner: ML with sleep, but modest gain. Sleep quality is a published health predictor, but it correlates strongly with depression, pain, and chronic conditions already in the model. The marginal information content of sleep — beyond what depression and disease burden capture — may be small.

Results

ROC Curves

Feature Importance (Top 8)

Sleep Quality vs Health Decline Rate

Multi-Model Comparison

Subgroup Analysis: Does Sleep Matter More for Some Groups?

Sleep’s predictive value may differ by age and sex. Do sleep measures help more for younger adults (where baseline risk is lower) or older adults (where comorbidities dominate)?

The ADM Insight

In this cohort, adding the available self-reported sleep-quality items changes held-out discrimination by only +0.002 AUC (area under the ROC curve, a 0–1 ranking measure) after health, depression, and function are included. This is a predictive result, not a causal one: it does not show that sleep is unimportant, nor that poor sleep is merely a symptom.

Cohort: HRS RAND respondents aged 50+ with sleep data in waves 10–15 (2010–2020). Outcome: significant health decline (self-rated health worsens by 1+ points) or mortality within 6 years.

Domain baseline: Standard health risk score plus a graded poor-sleep-quality composite. The sleep items are decoded according to the RAND HRS codebook: restless sleep, trouble falling asleep, waking early, waking at night, and rarely feeling rested in the morning.

ML Model 1 (No Sleep): GradientBoostingClassifier on standard health features — demographics, chronic conditions, functional status, depression, BMI, smoking, exercise.

ML Model 2 (+Sleep): Same GBM architecture with five decoded sleep-quality indicators plus their composite score. RAND variable RwSLEEPRT measures how often a respondent feels rested in the morning; it is not sleep duration.

Evaluation: 5-fold stratified cross-validation. Bootstrap 95% CIs from 1,000 resamples. Three-way comparison: domain baseline, ML without sleep, ML with sleep.

Limited follow-up: Sleep data only available from wave 10 (2010) onward, limiting the follow-up period compared to earlier investigations.

Self-reported sleep: All sleep measures are self-reported survey items. No polysomnography or actigraphy data are available to validate sleep quality objectively, and this RAND file does not provide sleep duration for this analysis.

No sleep apnea data: Obstructive sleep apnea — a major independent risk factor — is not captured in earlier HRS waves and may be underreported even when asked.

Reverse causation: Poor health may cause poor sleep, not just the other way around. This cross-sectional-to-longitudinal design mitigates but does not eliminate this concern.

Medication effects: Many medications (beta-blockers, SSRIs, corticosteroids) affect sleep quality. Medication use is not controlled for in these models.